
Kasper L, König A, Koenig P.-A, Gresnigt MS, Westman J, Drummond RA, Lionakis MS, Groß O, Ruland J, Naglik JR, Hube B (2018) |
The fungal peptide toxin Candidalysin activates the NLRP3 inflammasome and causes cytolysis in mononuclear phagocytes |
In: Nature Communications| (2018) 9:4260 |
fungal peptide toxin; Candidalysin; NLRP3 inflammasome; cytolysis; mononuclear phagocytes; microbes; phagocytes; innate immune system; inflammasome activation; host cytolysis; hypha formation; Pmacrophage lysis; inflammasome-dependent cell death; pyroptosis; late damage; glucose depletion; membrane piercing; cytolytic peptide; toxin; hypha-associated gene ECE1; NLRP3 inflammasome-dependent caspase-1 activation; potassium efflux; macrophages; dendritic cells; mononuclear phagocyte cell death; pyroptosis; glucose-consuming hyphae |
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